BRAF cDNA from syndromic SSA/Ps, hyperplastic polyps (HPs) and normal colon was amplified by PCR and sequenced since T to A mutations in codon 600 resulting in a valine to glutamic acid (V600E) amino acid change with increased kinase activity have been reported in SSA/Ps (Materials and Methods) [14]. This evidence concerns the gene BRAF and hyperplastic polyp.