A recent report also demonstrated a mechanism of deregulated NIK activity showing that a fusion oncoprotein of apoptosis inhibitor 2 and mucosa associated lymphoid tissue lymphoma translocation gene 1 cleaves NIK at R325 resulting in production of NIK lacking the TRAF3-binding site, which enables constitutive noncanonical NF-κB signaling in MALT lymphoma [34]. The gene discussed is TRAF3; the disease is MALT lymphoma.