To evaluate the activity of PI3K/AKT pathway both in PIK3CA mutant and PIK3CA wildtype groups, we consecutively selected a smaller series of PIK3CA wildtype patients with primary NSCLC, surgically resected between July 2008 and June 2009 with similar clinical and pathological characteristics from 1117 patients examined above. This evidence concerns the gene AKT1 and non-small cell lung carcinoma.