CHD5 and heart disorder: Two allelic mutations (9R9 and 13P2) affect CG32022 (Table 2), a gene that encodes a homolog of human Congenital Heart Disease 5 (Chd5)/Tryptophan-rich basic protein (Wrb), which is required for protein insertion into the endoplasmic reticulum membrane (Favaloro et al. 2010).