We hypothesize that the differential association of MYD88 and TRAF6 in with IRAK1 versus IRAK4 in DLBCL cell lines may be due in part to the homozygous versus heterozygous nature of the MYD88L265P mutation in OCI-LY3 cells as compared with either MWCL-1 or BCWM.1, respectively. The gene discussed is IRAK4; the disease is diffuse large B-cell lymphoma.