CYP2D6 and acute kidney injury: AKI induced by bilateral ureteric ligation or by Uranyl nitrate did not result in altered CYP-2D6 mediated metabolism of Metoprolol in rats [70,71]; no change in CYP2D6-mediated metabolism of Propranolol was observed in rats when AKI was induced by Cisplatin [66], but elevated Propranolol concentrations were observed, implying reduced CYP2D6 activity, when AKI was induced by bilateral ureteric ligation in rats [72].