Suppression of survivin by RNAi also enhanced the sensitivity of cancer cell lines to multiple treatments such as vincristine [116], 17-allylamino-17-demethoxygeldanamycin [108], doxorubicin [113,115], APO2L/TRAIL [109], TNF-alpha [113], and, as with AO and ribozymes, to radiation [113,114]. This evidence concerns the gene TNFSF10 and cancer.