GLA and Fabry disease: Mutations in the α-Gal A gene (GLA) occur in the rare, X-linked lysosomal storage disorder called Fabry disease, and resultant decreases in α-Gal A enzymatic activity lead to the progressive and widespread accumulation of glycosphingolipids in most bodily tissues and fluids including Gb3 and globotriaosylsphingosine (also known as lyso-Gb3) [1, 2].