NF-κB has been shown to play a role in TRAIL-induced Mcl-1 expression in HCT-116 colon cancer cells [17] and the interaction of p65 subunit with Naa10p reportedly regulates Mcl-1 expression [18], However, whether NF-κB is involved in Mcl-1 expression in human ESCC cells remains to be clarified. The gene discussed is MCL1; the disease is malignant colon neoplasm.