Moreover, although reports [17,18] have revealed that p65 subunit of NF-κB involves in TRAIL induced expression of Mcl-1 in HCT-116 colon carcinoma cells [17] and the interaction of p65 with N-a-Acetyltransferase 10 protein regulates Mcl-1 expression [18], the precise mechanism of Mcl-1 transcriptionally controlled by NF-κB family members is not fully elucidated. Here, NFKB1 is linked to colon carcinoma.