Carriers of BRCA1 or BRCA 2 tumor suppressor gene mutations face a high lifetime risk of breast and ovarian cancer, as well as a moderate increase in the risk of pancreatic, uterine body and uterine cervix cancers for BRCA1[43], and malignant melanoma, pancreatic, stomach, gallbladder and bile duct cancers for BRCA 2[44]. The gene discussed is BRCA1; the disease is bile duct cancer.