Moreover, some pilot studies [17,34] demonstrated an improvement in Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) and Systemic Lupus International Collaborating Clinics (SLICC) index upon TNFα depletion, suggesting TNFα-blockers could be taken into account as short-term induction therapy when dealing with refractory SLE. The gene discussed is TNF; the disease is systemic lupus erythematosus.