MTOR and neoplasm: It is worth repeating that we have found that six different types of chemotherapy including anti-metabolites, inhibitors of mTOR, microtubules, VEGF-R, PI3K and HSP90 [7] [and unpublished] in several different tumour-types implanted in both mouse and rat hosts, all showed a decrease in T1 in response to successful chemotherapy i.e. characterized by a significant change in TVol in comparison to vehicle-treated tumours.