Currently, it remains unclear to what extent the DKK-1 serum pool in breast cancer patients affected by bone metastasis is derived from tumor cells versus reactively enhanced bone remodeling and whether the suppression of DKK-1 by zoledronic acid has a beneficial effect on osteoblast/osteoclast activity at the site of an established bone lesion or might even prevent the establishment of disseminated tumor cells in the bone. Here, DKK1 is linked to breast carcinoma.