No significant correlation was found between HE4 in serum and HE4 in the peritoneal fluid; the HE4 serum versus the HE4 tumor/cyst fluid; the CA125 serum and the HE4 tumor/cyst fluid and the CA125 serum versus HE4 in peritoneal fluid when conducting the analysis of the total studied patient. The gene discussed is WFDC2; the disease is cyst.