Of the many treatment regimens tested in the Rip1Tag2 mice, including genetic ablation or sequestration of tumor- and angiogenesis-promoting factors (VEGF, insulin-like growth factor II, and fibroblast growth factors), and classical chemotherapy, the combined treatment with [Lys40(Ahx-DTPA-111In)NH2]-exendin-4 and vatalanib is one of the most efficient, with up to 97% smaller tumor volume in the interventional group, compared to 67% to 91% in previous studies [6]. This evidence concerns the gene IGF2 and neoplasm.