PITX2 and cholesteryl ester measurement: Some previously reported associations were replicated in this analysis such as the single nucleotide polymorphisms (SNPs) rs1906599 and rs12932445, located in the PITX2 (Paired-like homeodomain 2) and ZFHX3 (Zinc finger homeobox 3) genes respectively, and both related with CE etiology; or the SNP rs2383207 located in the CDKN2A/CDKN2B (Cyclin-dependent kinase inhibitor 2) gene, related with LAA stroke.