In particular, they observed that Dkk1-positive samples displayed higher expression level of epithelial marker E-cadherin and decreased expression of mesenchymal marker vimentin and cytoplasmic distribution of b-catenin than in Dkk1-negative samples, suggesting that the loss of Dkk1 in colon cancer could contribute to its progression and that Dkk1 was possibly associated with a reversal of the EMT process [36]. This evidence concerns the gene DKK1 and colonic neoplasm.