In summary, the data from our studies on the detection of micrometastasis in three types of gynecological cancer employing dual biomarkers clearly suggest that qRT-PCR seems to exhibit a slightly better diagnostic accuracy compared to IHC and corroborate previous studies, while the epithelial marker of CK19 when directly compared to the CA9 tumor-specific marker displays a rather consistent pattern of accurate detection of micrometastasis, which is independent of other variable tumor parameters, such as hypoxia and oxygen levels. Here, KRT19 is linked to female reproductive organ cancer.