VEGFA and age-related macular degeneration: Central to photoreceptor survival and function, the RPE is the major source of angiogenic (e.g., vascular endothelial growth factor (VEGF)) and antiangiogenic (e.g., pigment epithelium-derived factor (PEDF)) factors and therefore plays a central role in the modulation and progression of choroidal neovascularization [14–16] leading to AMD.