Membrane-type 1 MMP (MT1-MMP or MMP-14), which is expressed on the cell membrane, promotes the invasion of cancer cells by directly degrading extracellular matrix components, including fibronectin, vitronectin, laminin-1 and -5, fibrin, proteoglycans and collagen types I, II and III (20–22). The gene discussed is FN1; the disease is cancer.