CBFB and acute myeloid leukemia: The common chromosomal abnormalities in AML-M4 include monosomy 5 or del(5q), monosomy 7 or del(7q), trisomy 8, t(6;9)(p23;q34) and rearrangements involving the MLL gene mapped to 11q23 [del(11)(q23); t(9;11)(p22;q23), t(11;19)(q23;p13)] and core binding factor B (CBFβ) mapped to 16q22 [del(16)(q22), inv(16)(p13q22), t(16;16)(p13;q22)] (15).