However, in contrast to the majority of studies, certain studies have shown that a significant number of high-grade CIN and squamous cell carcinomas are negative for p16INK4A (20,21), and another study observed diffused or band-like p16INK4A staining patterns in specific cases of CIN I and SMH (22). The gene discussed is CDKN2A; the disease is cervical squamous intraepithelial neoplasia.