P-selectin played a key role in atherosclerosis and diabetes as a cell adhesion molecule; it was reported that an elevated level in circulating P-selectin was observed in diabetic patients [30, 31] in our recent study, we have verified resistin was targeted by miR-492 and was upregulated at mRNA and protein levels in high glucose stress HUVEC cells. Here, RETN is linked to atherosclerosis.