To generate a framework for studies of Docetaxel activity on PCa cells, we have developed six Docetaxel-resistant derivatives (IGR-CaP1-R5, -R12, -R25, -R50, -R100 and R200 respectively) of the IGR-CaP1 cell line [10], by periodically exposing proliferating cells to increasing doses of Docetaxel. Here, CAP1 is linked to posterior cortical atrophy.