Furthermore, several compounds known for their proapoptotic activities on tumor cells other than CLL are capable of activating Noxa: this is the case for tetramethoxystilbene (a resveratrol analog), isoliquiritigenin (a plant-derived flavonoid), phenoxodiol (a semisynthetic isoflavone) as well as celastrol (a triterpen proteasome inhibitor) [112–115]. Here, PMAIP1 is linked to neoplasm.