Furthermore, several compounds known for their proapoptotic activities on tumor cells other than CLL are capable of activating Noxa: this is the case for tetramethoxystilbene (a resveratrol analog), isoliquiritigenin (a plant-derived flavonoid), phenoxodiol (a semisynthetic isoflavone) as well as celastrol (a triterpen proteasome inhibitor) [112–115]. The gene discussed is PMAIP1; the disease is B-cell chronic lymphocytic leukemia.