A number of apoptosis inducers that upregulate Noxa in CLL cells have been mentioned above: bortezomib and other proteasome inhibitors, several HDAC inhibitors, hyperforin, acadesine, bendamustine, cisplatinium, vinblastine and other vinca alkaloids, PAS and aspirin. This evidence concerns the gene HDAC9 and B-cell chronic lymphocytic leukemia.