Moreover, the first pan-BH3 mimetic has been discovered: it is a SAHB modeled on the Bim BH3 domain (called Bim SAHB) that (i) targets a broad range of survival Bcl-2 proteins (Bcl-xL, Bcl-w, Mcl-1 and Al), (ii) induces caspase-dependent mitochondrial apoptosis in leukemia/lymphoma cells that are resistant to ABT-737 and (iii) suppresses tumor growth in a mouse model of acute myeloid leukemia [119]. The gene discussed is BCL2L11; the disease is acute myeloid leukemia.