For obesity treatment, this strategy may prove to be a more an effective strategy to reduce food intake than monohormone treatment, since the stimulation of GLP-1 secretion should lead to simultaneous release of the costored anorectic hormones CCK, glicentin, oxyntomodulin, and PYY, as reviewed (26). The gene discussed is CCK; the disease is obesity due to melanocortin 4 receptor deficiency.