INS and type 2 diabetes mellitus: In drug-naïve patients with T2DM, 52 weeks of treatment with VILDA or placebo, followed by a 12-week washout period, was studied using a hyperglycemic clamp with arginine stimulation to assess pancreatic islet-cell function and by a euglycemic-hyperinsulinemic clamp to determine the degree of tissue insulin resistance in each individual.