Rheumatoid arthritis (RA) is characterized by synovial inflammation and hyperplasia, autoantibody production such as rheumatoid factor (RF) and anti-citrullinated protein antibody (ACPA), cartilage and bone destruction, and systemic features, including cardiovascular, pulmonary, psychological, and skeletal disorders [1]. The gene discussed is PRTN3; the disease is rheumatoid arthritis.