To this end, a tissue material collected from patients with varying severity of streptococcal tissue infections, i.e., mild erysipelas (n = 11), to more severe STIs including severe cellulitis and necrotizing fasciitis (n = 6) (Table 1), were immuno-histochemically stained for HMGB1, bacterial load, and inflammatory cells. Here, HMGB1 is linked to sexually transmitted disease.