In addition, although previous studies suggested that the plasma ANP (a stimulator of lipolysis in AT [33]) is lower in obese than in lean individuals [34] (most likely linked to a higher expression of natriuretic peptide clearance receptors in AT with obesity [35]), our results showed no difference between O and L at Rest and during exercise. The gene discussed is NPPA; the disease is obesity due to melanocortin 4 receptor deficiency.