In addition to EM66, we have also reported that WE-14, a 14 amino-acid peptide derived from the proteolytic processing of CgA (CgA324-337) occurs in normal and tumoral (i.e. pheochromocytoma) human adrenochromaffin tissues [32] and that this peptide is secreted from pheochromocytes in primary culture [33]. The gene discussed is CGA; the disease is hereditary pheochromocytoma-paraganglioma.