CGA and hereditary pheochromocytoma-paraganglioma: Therefore, while our study needs to be substantiated in a larger group of patients and confirmed prospectively in an independent series, our present results suggest that combined measurement of granins and their derived peptides, such as CgA, WE-14 and EM66, should accompany routine assays of metanephrine levels for the diagnosis of pheochromocytoma.