Rac1 activation through ROCK inhibition in MCF-7 cells was expected, as ROCK antagonizes RhoA-dependent Rac1 activation in fibroblasts [42], and Rac inactivation through ROCK is occurs via FilGAP phosphorylation or ARHGAP22 activation in melanoma cells [43], [44]. The gene discussed is AKT1; the disease is melanoma.