In the subgroup analysis by ethnicity, the results indicated that there was significant association between IL-10 -592A/C polymorphism and TB risk in Asians under all gene models (C allele vs. A allele: OR =  0.69, 95% CI = 0.57–0.85, P<0.01; CC+AC vs. AA: OR = 0.65, 95% CI  =  0.49–0.85, P = 0.002; CC vs. AC+AA: OR =  0.62, 95% CI = 0.49–0.79, P<0.01; CC vs. AA: OR =  0.49, 95% CI = 0.34–0.71, P<0.01; AC vs. AA: OR = 0.70, 95% CI = 0.55–0.89, P<0.01), but not in Europeans, Africans, and Americans, suggesting genetic diversity among ethnicities. Here, IL10 is linked to tuberculosis.