Univariate analysis demonstrated that the overall 5-year survival rate of patients with BRF2 protein high expression was significantly lower than that of the remaining patients among squamous cell carcinoma, and we also found such a trend in adenocarcinoma, despite the statistical analysis does not make sense; (P = 0.007 and P = 0.130, respectly; Fig. 4). The gene discussed is BRF2; the disease is adenocarcinoma.