An understanding of the physiological tumor suppressor role of Dok1 emerged from mice studies, revealing a significantly accelerated onset of the p210bcr-abl-induced chronic myelogenous leukemia (CML), a myeloproliferative disorder of the hematopoietic stem cell, upon Dok1 inactivation [59], [72]. Here, DOK1 is linked to myeloproliferative disorder.