The rationale for this includes the previous observation that single allelic loss of SYK in a mouse model led to enhanced invasion, proliferation, and tumor formation in the mammary gland; Syk knockdown in cells results in an epithelial-to-mesenchymal (EMT)-like transition with enhanced invasiveness; and Syk re-expression in breast cancer cell lines prevents tumor growth and metastasis in mouse models [2], [3], [5]. This evidence concerns the gene SYK and breast carcinoma.