A possible explanation for the regional effect of deleting Chop and Ask1 is that since older photoreceptors reside in the central retina and are known to die faster than younger peripheral photoreceptors in different RP models [9], [58], deleterious effects associated with the expression of Chop and Ask1 occur earlier in these cells than cells in the retinal periphery. The gene discussed is MAP3K5; the disease is retinitis pigmentosa 1.