AKT1 and cancer: Two papers are on cancer cells: Han-Peng Kuo et al. reported that Ganoderma tsugae extract inhibited the growth of HER2-overexpressing cancer cells and enhanced the growth inhibitory effect of antitumor drugs via the modulation of HER2/PI3K/Akt signaling pathway; Xiu-Feng Wang et al. showed that PC-SPESII herbal extract could impair human breast cancer metastasis by regulating proteolytic enzymes and matrix dynamics through the p38MAPK and SAPK/JNK pathway.