In agreement with this findings, an elegant recent study demonstrated that decreasing the expression of two of the eIF2α kinases, double-stranded RNA-activated protein kinase (PKR)-like endoplasmic reticulum kinase (PERK) and General control non-derepressible-2 (GCN2), improve cognitive function and synaptic plasticity in an AD transgenic mouse model (Ma et al., 2013). Here, EIF2AK3 is linked to Alzheimer disease.