C3 and obesity due to melanocortin 4 receptor deficiency: Taken together with ASP proinflammatory effects on adipose tissue, such as stimulation of inflammatory cytokine production and macrophage infiltration/M1 polarization [37, 38], the altered ASP/C5L2 ratio in omental tissue may be both reflective of impaired ASP functionality as well as contributing to the dyslipidemia and metabolic disturbances of obesity.