Further, as demonstrated in Figure 2(d), although C5aR expression decreased in both tissues with increasing obesity levels, there was a proportionally greater decrease in omental tissue, such that the subcutaneous/omental ratio of C5aR expression tended to increase with increasing levels of obesity (linear trend P < 0.05). The gene discussed is C5AR1; the disease is obesity due to melanocortin 4 receptor deficiency.