Furthermore, obesity-associated adipose tissue metabolic complications such as an imbalance in lipogenesis/lipolysis, delayed triglyceride clearance, dysregulated adipokine, and C3 (ASP precursor) production, as well as fat accumulation, all exert profound impacts on ASP secretion [6, 27]. The gene discussed is C3; the disease is obesity due to melanocortin 4 receptor deficiency.