Taken together with ASP proinflammatory effects on adipose tissue, such as stimulation of inflammatory cytokine production and macrophage infiltration/M1 polarization [37, 38], the altered ASP/C5L2 ratio in omental tissue may be both reflective of impaired ASP functionality as well as contributing to the dyslipidemia and metabolic disturbances of obesity. This evidence concerns the gene C5AR2 and Obesity.