Already a previous study by Mellado et al. had shown that CCR5 plays a key role in inducing apoptotic death in tumor infiltrated lymphocytes (TIL) in a CCL5-dependent manner: CXCL12 released by melanoma cells induced the expression of CCL5 by TIL, which in turn activated their death program [77]. The gene discussed is CCR5; the disease is melanoma.