MKI67 and neoplasm: Another study evaluated the long-term outcome of patients after NET, showing that a low-risk profile (i.e. pT0/1, pN0, Ki6-67 <2.7 % and Allred score 3–8 for ER status, the so-called PEPI score) allowed to identify a group of patients with a very low risk of disease progression.49 Our data are in agreement with these results only for pathological stage, but not for Ki-67 and ER status, likely for the very high ER positivity and G1 tumor percentage in our patients’ population, as emphasized above.