Recent studies have indicated that obesity in both human and animal is actually a state of chronic low--grade inflammation, which is characterized by the increase of local and circulating proinflammatory adipokines secreted mainly by enlarged visceral white adipocytes, including tumor necrosis factor alpha (TNFα), interleukins (ILs), leptin, and adiponectin [1–3]. This evidence concerns the gene TNF and obesity due to melanocortin 4 receptor deficiency.