In the study by Schäfer et al (2014), keratinocyte-specific expression of constitutively active Nrf2 in mice led to SG enlargement and seborrhea with hyperkeratosis and acanthosis of the hair follicle infundibuli and interfollicular epidermis, thus replicating some characteristics of non-inflammatory acne in humans. This evidence concerns the gene NFE2L2 and Hyperkeratosis.