Evidence of Lewy body disease, multiple system atrophy, Alzheimer's disease or amyotrophic lateral sclerosis; semantic or logopenic variant primary progressive aphasia; structural lesion suggestive of focal cause; granulin mutation or reduced plasma progranulin levels; TDP-43 or fused in sarcoma (FUS) mutations. The gene discussed is TARDBP; the disease is multiple system atrophy.