Although VEGF binding to NRP1 appeared to be largely dispensable for embryonic angiogenesis, the study of newborn and adult Nrp1Y297A/Y297A mice revealed essential roles for NRP1 in postnatal angiogenesis and arteriogenesis in the heart and retina, and in pathological neovascularization in a model of neonatal eye disease [20]. Here, NRP1 is linked to eye disorder.