In AD, as well as the majority of mammalian AD models, Aβ must be generated by amyloidogenic proteolytic processing of APP, a process that reportedly occurs at both plasma membrane (Armstrong, 1998; Takahashi et al., 2002b; Marchesi, 2005) as well as intracellular AEL vesicles (Cataldo et al., 2004; Yu et al., 2005). This evidence concerns the gene APP and Alzheimer disease.