APP and Alzheimer disease: Our results are also broadly in accordance with AD as well as some mammalian AD models where neurons preferentially produce Aβ1–40 from APP proteolysis (Hartmann et al., 1997), but paradoxically accumulate higher levels of intraneuronal Aβ1–42 (Gouras et al., 2000, 2005; Laferla et al., 2007).