However, as one of the transcription factors that regulates expression of PDK4, the PGC1α promoter was reported to be hyper-methylated in skeletal muscle of T2D subjects [38] and after overfeeding fat to low birth weight individuals [39], indicating that altered methylation patterns associated with metabolic disease may be promoter specific [37]. The gene discussed is PDK4; the disease is type 2 diabetes mellitus.