The secretion of these enzymes in response to different stimuli has been reported in many studies; for example, glycolytic enzymes are secreted as immunogens during infection by Candida albicans[16,38,70], and GAPDH and enolase may be secreted during invasion by pathogens, as they bind to various mammalian proteins such as lysozyme, fibronectin, actin, myosin, and plasmin[16,38,70]. This evidence concerns the gene GAPDH and infection.