Increasing evidence suggests that NAFLD/NASH and CKD share several traditional and non-traditional cardio-metabolic risk factors including higher plasma inflammatory and hemostatic factors, hyperuricemia, lower circulating insulin-like growth factor-1 (IGF-1) levels, endothelial dysfunction, and oxidative stress biomarkers [17]–[26]. The gene discussed is IGF1; the disease is metabolic dysfunction-associated steatohepatitis.